In a vast world divided into three realms, a land of rampant demons and monsters, the genius sect master of the Medicine God Sect, who was unable to cultivate his entire life, seeks a path to reincarnation and rebirth as his life nears its end. However, the sea of life and death is deep, the path of reincarnation is perilous, karma entangles, and calamities befall. Three hundred years later, in the mortal-filled Qian Xuan Continent, a border town, the precarious Yu family, a young man with lost soul and earth soul, awakens one night. From then on, the world changes, legends and myths continue. The reborn youth, his earth soul condenses into a Yin spirit, his heaven soul advances to a Yang spirit, and his human soul transforms into a primordial spirit. Finally, the three souls become invincible!